Search results for "Whole body irradiation"

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WHOLE BODY IRRADIATION INDUCES IFN-γ PRODUCTION IN BALB/c MICE BY PREVENTING THE APPEARANCE OF A Vα14+NK T DOWNREGULATORY POPULATION

2000

Lymph node cells from TNCB-immune BALB/c mice fail to produce IFN-gamma when exposed to antigen in vitro. Conversely, lymph node cells of irradiated (550 rads) BALB/c mice produce IFN-gamma. Transfer experiments show that normal BALB/c mice contain cells which suppress IFN-gamma production. These downregulatory cells are CD4(+)alpha beta(+)and rearrange the invariant V alpha 14-J alpha 281 T cell receptor alpha chain, thus belonging to the NK T cell subset. Downregulatory cells probably act by producing IL-4 as their effect is blocked by mAb to IL-4.

CD4-Positive T-LymphocytesMalemedicine.drug_classCD8 AntigensReceptors Antigen T-Cell alpha-betaImmunologyPopulationWhole body irradiationAntigen-Presenting CellsDown-RegulationAntigens ProtozoanEnzyme-Linked Immunosorbent AssayCell SeparationMonoclonal antibodyBiochemistryBALB/cInterferon-gammaMiceAntigenmedicineAnimalsImmunology and AllergyeducationMolecular BiologyLymph nodeLeishmania majorMice Inbred BALB Ceducation.field_of_studybiologyChemistryT-cell receptorAntibodies MonoclonalHematologyFlow Cytometrybiology.organism_classificationMolecular biologyIn vitroKiller Cells NaturalPhenotypemedicine.anatomical_structureCD4 AntigensImmunologyInterleukin-4Lymph NodesSpleenCytokine
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